| Description
: |
A white or almost
white, crystalline fine powder, colourless needles |
| Solubility
: |
Slightly soluble in
water, sparingly soluble in boiling water and in alcohol. |
| Identification
: |
A) BY TLC: The
principal spot in the chrometogram obtained with the test
solution is similar in position, colour and size to the
principal spot in the chromatogram obtained with the
reference solution.
B) A green colour develops when treated with bromine water
and ammonia
C) An intense blue fluorescence appears at 366nm when
treated with dilute sulphuric acid which disappear
completely by adding lml of HCL.
D) The solution in dilute HCL gives reaction of Sulphate.
E) The pH of 1.0% solution in water is 5.7 to 6.6. |
| Appearance
of Soln. : |
Solution S is clear
and not
more intensely coloured than reference
solution GY6. |
| pH : |
pH is 5.7 to 6.6
(1 % suspension in water) |
| Specific
Optical : |
-237" to -245' |
| Rotation
: |
(0.500 g in 25mI of
0.1 M HCL) |
| Other
Cinchona : |
Dihydroquinine : NMT
10.0% |
| Alkaloids
: |
Imp.Bedore Quinine :
NMT 5.0% |
| (By
HPLC) : |
Any Other Impurity :
NMT 2.5% |
| Loss
on Drying : |
3.0% to 5.0% w/w
(Determined with 1.000g@ 105ºC) |
| Sulphated
Ash : |
NMT 0.1% w/w
(Determined on 1.0g) |
| Assay
: |
99.0% to 101.0% on
dried basis |
ORGANIC
COMPOUNDS
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